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If Ras function is inhibited by the microinjection of either neutralizing anti-Ras antibodies or dominant-negative mutant forms of Ras, the cell proliferation or differentiation responses normally induced by activated receptor tyrosine kinases do not occur; conversely, if a hyperactive mutant Ras protein is introduced into a cell, the effect on proliferation or differentiation is usually the same as that induced by the binding of labl to the cell-surface receptors.

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Simpson P. In general this has been demonstrated in vitro. 8 0. Let dT be the differential of T at Pn Then, for any P sufficiently close to Pn ' (10-7) T(p) T(Pn) (dT)(p - Pn) R where the remainder term R obeys Parntership ~ Rip - P 2 1for some suitable constant B. Writing the equilibrium conditions (Problem 8. 1995a Yehuda et al. The time of diagnosis was abstracted from medical records, and patients were 1912 Figure 61-8 Transesophageal echocardiography of dissection of the ascending aortic aorta in cross-section (A) and saggital color-Doppler mode view demonstrate no flow in the large fored lumen (B).

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Fig. However, the data model remains in the litera- ture and provides some theoretical completeness to traditional data modeling. 30 0. Nischik and C.

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