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The threshold value for autoregulatory failure is variable between patients and can be shifted higher or lower by prior ischemic injury or long standing hypertension. Implicitfunctions. Moreover,inpartduetotheseminalworkcarriedoutby Prange and collaborators in the United States in the 1960s, the use of thyroid hormones in augmenting antidepressant response in depression was estab- lished.

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